徐剑, 杨毅敬, 覃艮艳, 周亚莎, 彭俊, 彭清华. 枸杞子配伍丹参对RCS（rdy-/-, p-/-）视网膜色素变性大鼠虚中夹瘀证的干预研究[J]. Digital Chinese Medicine, 2019, 2(3): 157-165. DOI: 10.1016/j.dcmed.2019.12.004
引用本文: 徐剑, 杨毅敬, 覃艮艳, 周亚莎, 彭俊, 彭清华. 枸杞子配伍丹参对RCS（rdy-/-, p-/-）视网膜色素变性大鼠虚中夹瘀证的干预研究[J]. Digital Chinese Medicine, 2019, 2(3): 157-165. DOI: 10.1016/j.dcmed.2019.12.004
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XU Jian, YANG Yi-Jing, QIN Gen-Yan, ZHOU Ya-Sha, PENG Jun, PENG Qing-Hua. Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention Study[J]. Digital Chinese Medicine, 2019, 2(3): 157-165. DOI: 10.1016/j.dcmed.2019.12.004
Citation: XU Jian, YANG Yi-Jing, QIN Gen-Yan, ZHOU Ya-Sha, PENG Jun, PENG Qing-Hua. Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention Study[J]. Digital Chinese Medicine, 2019, 2(3): 157-165. DOI: 10.1016/j.dcmed.2019.12.004
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枸杞子配伍丹参对RCS（rdy-/-, p-/-）视网膜色素变性大鼠虚中夹瘀证的干预研究

Effects of Lycii Fructus and Salviae Miltiorrhizae on the Syndrome of Deficiency with Blood Stasis in RCS (rdy-/-, p-/-) Rats with Retinitis Pigmentosa: An Intervention Study

    摘要
  • 摘要:
    目的探讨枸杞子和丹参对RCS（rdy-/-, p-/-）视网膜色素变性大鼠虚中夹瘀证的影响。
    方法将32只RCS（rdy-/-, p-/-）大鼠分为四个组（每组雌雄各半），根据灌胃药剂不同分为：模型组给予生理盐水0.9%进行治疗，枸杞子（LF）组给予枸杞配方颗粒溶剂，丹参（SM）组给予丹参配方颗粒溶剂，枸杞和丹参（L·S）组给予丹参配方颗粒和杞子配方颗粒混合溶剂。将8只RCS（rdy +/+, p +/+）大鼠（雌雄各4只）作为空白组，用0.9%生理盐水灌胃处理。灌胃28天后，我们检测了各组大鼠血液中E2、PG、P-选择素的含量、血浆黏度、高剪切率全血相对指数和血浆中的纤维蛋白原含量，视网膜匀浆中的cAMP、cGMP含量，并通过HE染色评估视网膜。
    结果L·S组血浆中E2、PG、P-选择素的含量、血浆黏度、高剪切率全血相对指数和血浆纤维蛋白原含量与模型组相比有显着性差异（P < 0.01），并且类似于空白组。L·S组视网膜匀浆中cAMP、cGMP的含量与模型组差异有统计学意义（P < 0.01），与空白组相似（P > 0.05）。
    结论枸杞子和丹参可改善虚中夹瘀证，有效干预视网膜色素性。

     

    Abstract:
    ObjectiveTo investigate the effects of Lycii Fructus (LF, Gou Qi Zi, 枸杞子) and Salviae Miltiorrhizae Radix Ex Rhizoma (SM, Dan Shen, 丹参) on the syndrome of deficiency with blood stasis in the RCS (rdy-/-, p-/-) rats with retinitis pigmentosa (RP).
    MethodsA total of 32 RCS (rdy-/-, p-/-) rats were divided into 4 groups (equal amounts of female and male rats in each group): model group treated with 0.9% normal saline, LF group treated with LF formula granules, SM group treated with SM formula granules, and LF and SM (L·S) group treated with LF and SM formula granules. Eight RCS (rdy+/+, p+/+) rats (4 males and 4 females) were treated with 0.9% normal saline to serve as blank group. The contents of E2, PG, P-Selectin, plasma viscosity, whole blood relative index of the high shear rate and fibrinogen content in plasma, and the content of cAMP and cGMP in retinal homogenate were detected. The retina was evaluated by hematoxylin-eosin staining.
    ResultsThe contents of E2, PG, P-Selectin, plasma viscosity, whole blood relative index of the high shear rate, and fibrinogen content in the plasma of L·S group significantly differed from those of model group (P < 0.01), but were similar to those of blank group. The contents of cAMP and cGMP in the retinal homogenate of L·S group significantly differed from those in model group (P < 0.01) but were similar to those in blank group (P > 0.05).
    ConclusionsLF and SM can effectively treat retinitis pigmentosa by ameliorating the syndrome of deficiency with blood stasis.

     

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