Abstract: The Quality 4.0 concept is derived from the industrial fourth revolution, i.e., Industry 4.0. Quality 4.0 is the future of quality, where new digital and disruptive technologies are used to maintain quality in organizations. It is also suitable for traditional Chinese medicine (TCM) to maintain quality. This quality revolution aims to improve industrial and service sectors’ quality by incorporating emerging technologies to connect physical systems with the natural world. The proposed digital philosophy can update and enhance the entire TCM treatment methodology to become more effective and attractive in the current competitive structure of the pharmaceutical and clinical industries. Thus, in healthcare, this revolution empowers quality treatment during the COVID-19 pandemic. There is a major requirement in healthcare to maintain the quality of medical tools, equipment, and treatment processes during a pandemic. Digital technologies can widely be used to provide innovative products and services with excellent quality for TCM. In this paper, we discuss the significant role of Quality 4.0 and how it can be used to maintain healthcare quality and fulfill challenges during the pandemic. Additionally, we discuss 10 significant applications of Quality 4.0 in healthcare during the COVID-19 pandemic. These technologies will provide unique benefits to maintain the quality of TCM throughout the treatment process. With Quality 4.0, quality can be maintained using innovative and advanced digital technologies.