王朝平, 罗晶, 万强, 曹美芳, 查青林, 雷志强, Abid Naeem, 杨明. 基于数据挖掘分析芳香中药治疗心绞痛古今用药规律[J]. Digital Chinese Medicine, 2022, 5(2): 123-140. DOI: 10.1016/j.dcmed.2022.06.003
引用本文: 王朝平, 罗晶, 万强, 曹美芳, 查青林, 雷志强, Abid Naeem, 杨明. 基于数据挖掘分析芳香中药治疗心绞痛古今用药规律[J]. Digital Chinese Medicine, 2022, 5(2): 123-140. DOI: 10.1016/j.dcmed.2022.06.003
WANG Chaoping, LUO Jing, WAN Qiang, CAO Meifang, ZHA Qinglin, LEI Zhiqiang, Abid Naeem, YANG Ming. Ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris based on data mining[J]. Digital Chinese Medicine, 2022, 5(2): 123-140. DOI: 10.1016/j.dcmed.2022.06.003
Citation: WANG Chaoping, LUO Jing, WAN Qiang, CAO Meifang, ZHA Qinglin, LEI Zhiqiang, Abid Naeem, YANG Ming. Ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris based on data mining[J]. Digital Chinese Medicine, 2022, 5(2): 123-140. DOI: 10.1016/j.dcmed.2022.06.003

基于数据挖掘分析芳香中药治疗心绞痛古今用药规律

Ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris based on data mining

  • 摘要:
    目的探讨芳香中药治疗心绞痛古今用药规律,为心绞痛的临床用药提供有效依据。
    方法以“心绞痛”为关键词,检索时限为2015年1月1日至2021年12月31日,通过中国知网、中国中医药数据库、中药方剂数据库、《新编国家中成药》(第二版)、《中国药典》(2020版)等收集与心绞痛相关的古籍方剂和中成药处方。挖掘核心高频芳香中药,分析总结其潜在用药规律。利用Microsoft Access 2010进行数据管理,采用数据分析软件Excel和IBM SPSS Modeler 18.0 进行药物关联规则分析,Cytoscape 3.7.2进行可视化展示。
    结果从相关数据库收集到治疗心绞痛且含芳香中药的古籍方剂有67个,中成药处方有258个。古籍方剂中使用频率≥10的芳香中药有9味,最常用的是当归,其次是陈皮;中成药处方中使用频次≥10的芳香中药有33味,最常用的是丹参,其次是川芎和三七。古籍方剂中以温里药、理气药和活血化瘀药为主,古籍方剂中置信度等于100%的药对有8对,使用频率最高的药对是川芎+当归和香附+陈皮;中成药处方中芳香中药川芎可与多味中药进行配伍,其中川芎+丹参的置信度和支持度处于较高水平。
    结论治疗冠心病心绞痛的芳香中药主要为温性,五味中以辛、甘和苦为主,主要归肝、胆和心包经。冠心病心绞痛治疗主要以温通心脉、活血化瘀为主。

     

    Abstract:
    Objective To explore ancient and modern medication laws of aromatic Chinese medicines in treating angina pectoris, and to provide new ideas for the clinical treatment.
    MethodsWith “angina pectoris” as the key word, ancient books prescriptions and Chinese patent medicines related to angina pectoris were collected from China National Knowledge Infrastructure (CNKI), Traditional Chinese Medicine Database System, Chinese Medicine Prescription Database, New National Proprietary Chinese Medicine (2nd edition), and Chinese Pharmacopoeia (2020 edition) from January 1, 2015 to December 31, 2021. Core high-frequency aromatic Chinese medicines were defined, and their potential medication rules were analyzed and summarized. Microsoft Access 2010 was used for data management. Data analysis software, including Excel and IBM SPSS Modeler 18.0 were used for drug association rule analysis, and Cytoscape 3.7.2 for visual display.
    ResultsThere were 67 ancient books prescriptions and 258 Chinese patent medicines containing aromatic Chinese medicines treating angina pectoris collected from relevant databases. In ancient books prescriptions, there were nine aromatic Chinese medicines with the frequency ≥10, and the most commonly used medicine was Danggui (Angelicae Sinensis Radix), followed by Chenpi (Citri Reticulatae Pericarpium). There were 33 aromatic Chinese medicines with the frequency ≥10 in Chinese patent medicines, and the most commonly used medicine was Danshen (Salviae Miltiorrhizae Radix et Rhizoma), followed by Chuanxiong (Chuanxiong Rhizoma) and Sanqi (Notoginseng Radix et Rhizoma). In ancient books prescriptions, the medicines mainly belonged to intenal-warming medicines, Qi-regulating medicines, and blood circulation promoting and blood stasis removing medicines. There were eight medicine pairs with confidence equal to 100% in ancient books prescriptions, the most frequently used pairs were Chuanxiong (Chuanxiong Rhizoma) + Danggui (Angelicae Sinensis Radix), and Xiangfu (Cyperi Rhizoma) + Chenpi (Citri Reticulatae Pericarpium). In Chinese patent medicines, the aromatic Chinese medicine Chuanxiong (Chuanxiong Rhizoma) could be combined with many other Chinese medicines, among which the Confidence and Support of Chuanxiong (Chuanxiong Rhizoma) + Danshen (Salviae Miltiorrhizae Radix et Rhizoma) were at a high level.
    ConclusionAromatic Chinese medicines for the treatment of angina pectoris of coronary heart disease are mainly warm, and the flavors are mainly pungent, sweet, and bitter. They mainly access to the liver, gallbladder, and pericardium meridians. The treatment of angina pectoris of coronary heart disease mainly focuses on warming heart pulse, and promoting blood circulation and removing blood stasis.

     

/

返回文章
返回