Objective To configure the complex traditional Chinese medicine (TCM) prescription using digit topology circle and to derive digit topology circle.

Methods The basic digit topology circles were constructed. Different digit topology circles were derived using basic digit topology circle, the character strings, and the digit groups. Different digit topology circles with ternary Chinese medicine were derived by adding ternary Chinese medicine into digit topology circles. The valuable TCM prescriptions were configured using the derived digit topology circles.

Results Nine simple basic digit topology circles were constructed from the character strings. Multiple digit topology circles and some digit topology circles with ternary Chinese medicine were derived using basic digit topology circles, the character strings, and the digit groups. Four complex TCM prescriptions were configured using four derived digit topology circles digit topology circles, respectively.

Conclusion The digit topology circles can be used to configure some existing TCM prescriptions and many novel TCM prescriptions. It has been verified that some existing TCM prescriptions have been used successfully to treat patients with diseases. Some novel valuable TCM prescriptions configured by digit topology circles may be used to treat patients with diseases.