中医药植物疗法治疗垃圾食品诱导的肥胖和代谢紊乱

Traditional Chinese medicine-based phytotherapeutics for junk food-induced obesity and metabolic dysfunction

  • 摘要: 肥胖是由高糖高脂饮食驱动的全球性健康问题,与代谢综合征、糖尿病及心血管疾病密切相关。现代研究表明,垃圾食品通过影响脂肪代谢、肠道菌群及炎症等途径引发代谢紊乱。中医药秉持整体观念,强调脏腑功能与气血平衡,其药用植物中含有多类活性成分,具有调节能量代谢和改善代谢失衡的潜力。本综述系统总结了中草药调控肥胖的主要作用机制,包括抑制食欲、调节脂代谢、促进产热、改善肠道菌群以及抗炎、抗氧化等。在实验及临床中人参、荷叶、葛根、桂皮、绞股蓝等代表性药材具有调脂、降糖和改善炎症反应的作用。总体而言,中医药植物疗法通过多途径调节来纠正代谢失衡是一种整体和安全的方法。然而,还需要通过标准化配方、机制验证和大规模临床试验来确定其疗效和转化价值。未来将传统知识与生物医学研究相结合有助于中医药植物疗法形成科学性的肥胖预防和管理策略。

     

    Abstract: Obesity driven by high-sugar and high-fat dietary patterns has become a major global health challenge and is closely associated with metabolic syndrome, diabetes, and cardiovascular disorders. Growing evidence indicates that junk food disrupts lipid metabolism, alters gut microbiota, and triggers chronic inflammation, leading to systemic metabolic dysfunction. Traditional Chinese medicine (TCM), rooted in holistic regulation of organ systems, blood circulation, and energy balance, offers multi-target plant-based strategies for modulating obesity. This review summarizes key mechanisms through which Chinese medicinal plants counteract obesity, including appetite suppression, regulation of lipid metabolism, activation of thermogenesis, modulation of gut microbiota, and anti-oxidative and anti-inflammatory actions. Representative herbs such as Panax ginseng, Nelumbo nucifera, Cinnamomum cassia, Gynostemma pentaphyllum, and Pueraria lobata exhibit lipid-lowering, glucose-regulating, and inflammation-modulating activity in experimental and clinical studies. Overall, TCM herbal therapies provide a holistic and safe approach to correcting metabolic imbalance through multi-pathway regulation. However, standardized formulation, mechanistic validation, and large-scale clinical trials are urgently required to establish their efficacy and translational value. Future work integrating traditional knowledge with biomedical research will help position TCM-based phytotherapy as a scientifically grounded strategy for obesity prevention and management.

     

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