Effect of the Fu Zheng Method Applied by Hong-Feng CHEN on the Quality of Life in TNBC Patients and Empirical Research Based on Data Mining

ObjectiveTo preliminarily evaluate the efficacy of the Fu Zheng method (supporting resistance against pathogenic factors) applied by Professor Hong-Feng CHEN in improving the quality of life in patients with triple-negative breast cancer (TNBC) to collect and organize the traditional Chinese medicine (TCM) formulas applied by Professor Hong-Feng CHEN in the treatment of TNBC in order to explore the patterns in prescription.

MethodsThe Functional Assessment of Cancer Therapy-Breast scale (FACT-B V4.0) were collected before and after treatment; the database and data mining platform for prescribed TCM formulas were constructed using Microsoft SQL Server 2005, and the patterns in drug pairing and combination were summarized by correlation analysis of data mining.

ResultsThe formulas improved the mean scores of the patients' physical well-being, social/family well-being, emotional well-being, physical function well-being and additional concerns (P < 0.01); the drug combinations and pairs frequently used by Professor Hong-Feng CHEN were summarized.

ConclusionThe TCM formulas applied by Professor Hong-Feng CHEN can alleviate adverse physiological reactions, improve psychological conditions and improve function in patients. The formulas take spleen invigoration and stomach nourishment as well as blood circulation promotion and stagnation dissipation as the therapeutic principles, with simplicity in prescription and focus on care and protection the foundation of acquired constitution.